Listed Biotechnology Companies Q-Z
This Page Last Updated On 15/2/2024
RAC - Race Oncology Ltd.
The company listed in July 2016 through an RTO of Coronado Resources and is seeking to rejuvenate a chemotherapy drug Bisantrene previously used by Lederle but was lost in the series of pharma mergers in the 1990s. The company's initial goal is to complete clinical development of the drug and gain USFDA approval. In the two years since listing, shares have risen by up to 80% but are now down around 50% on opening price (down 85% in 2018 to $6 million). A recent short term (November 2018) 114% jump in share price to $17 million remains unexplained and there was a 153% increase to $21 million in 2019 with a recent fillip given by commencement of clinical trial in Israel, new successful fund raising and better promotion in the market. There was a further 821% increase in 2020 to $227 million with speculation followed by positive clinical trial results and a recent 30% boost with announcement of positive preclinical results. There was a further 106% increase in 2021 to $574 million. There was a 44% decrease in 2022 to $324 million with clinical trial in Israel extended into Phase 2 due to positive results with short term 30% share increase. There was a 58% decrease in 2023 with company value at $137 million with increasing emphasis on Bisantrene for cardioprotection and clinical studies and relaunch of modified company strategy and appointment of new CEO. There has been little change in 2024 at $138 million. (13/2/24)RAD - Radiopharm Theranostics Ltd.
Melbourne based theranostic company formed in 2021 to develop radiopharmaceutical products was listed on the ASX in late 2021 at an indicative value of $152 million, relying on four proprietary technologies. There was a 70% decrease in 2022 to $39 million following fund raising with progress being made on registrations and trials. There was a 30% decrease in 2023 to $28 million with partnership with GenesisCare to develop novel therapeutic radiopharmaceuticals in Australia and gaining orphan drug designation and well as progress on IND application. There has been a 15% decrease in 2024 to $25 million. (8/2/24)RCE - Recce Pharmaceuticals Ltd.
Company developing a diverse portfolio of synthetic antibiotics started by former founder of Chemeq Limited which collapsed in controversial circumstances in 2007. Initially raised $5 million in early 2016 with a company value of $13 million and although shares rose 90% on listing, they had returned to parity by the end of 2016. Shares increased 3% in 2017 to $15 million with refocussing of company to target antibiotics and antivirals and halting of work on anticancer treatments. There was a 60% speculative jump in September with television exposure of company and this led to new fund raising which was successfully completed. Company is changing name to Recce Pharmaceuticals. There was a 3% increase in 2018 with company value at $15 million and increased exposure of the company overseas and there was a 106% increase in 2019 to $48 million with funds raised and reorganisation of the Board. There was a 193% increase in 2020 to $183 million with clinical trials advancing, resignation of founder and Chief Research Officer, appointment of new CEO and selection for inclusion in Melbourne and US Covid antivirus screening programs which are progressing to a clinical stage. There was a 2% decrease in early 2021 with company value at $179 million with new trials planned. There was a further 36% decrease in 2022 to $118 million with clinical trials progressing but tests of lead product in animals provided inconclusive results . There was a 19% decrease in 2023 to $109 million with new patent protection, trial progressing and positive response from use of medication in special access patients. Raising funds has depressed prices. There has been a 6% decrease in 2024 to $103 million despite positive clinical trial results. (15/2/24)RGS - Regeneus Ltd.
Stem cell development company listed in September 2013 and has been more modest in its approach than Mesoblast. Currently promoting a canine cancer vaccine and use of adipose-derived stem cells for osteoarthritis and tendinopathy. Following listing, shares increased 100% by the end of 2013 to company value of $85 million but there was a 65% decline in 2014 to company value of $33 million with launch of cancer vaccine for dogs, a new agreement with Cryosite (ASX:CTE), new fund raising completed and launch of osteoarthritis treatment in Singapore. A negative report in ABC’s 7:30 report depressed prices in October 2014. There was a substantial switching of seats in the Board and management with a strategic review to reduce costs. Approval to proceed with clinical trial of a cancer vaccine has led to some recovery, down 41% at $20 million in 2015. There was an unexplained 70% increase in 2016 to $33 million (eventually up 76% at $34 million) with collaboration in Japan which is already providing income. There was a 24% decrease in 2017 to $26 million with a milestone payment for a successful trial in Japan and there had been a decline and recovery in 2018 to $25 million (down 4%) with promising trial results. Announcement of licensing opportunities in Japan and new funding resulted in a 50% jump in July (eventually up 44% at $38 million). There was a 52% decline in 2019 to $24 million with appointment of new CEO to drive commercialisation, new funds raised and a significant Japanese investor taking up a shortfall in a rights issue. There was a 44% increase in 2020 to $38 million with licensing agreement with and payment of fee by Kyocera in Japan for stem cell treatment of knee osteoarthritis. There was a 36% decrease in 2021 to $25 million with two milestone payments providing profitability for the company. There was a 40% decrease in 2022 to $15 million. There was a further 94% decrease in 2023 to $1 million with Kyocera terminating licensing agreement. The company has agreed to merge with a US company, Cambium Medical Technologies which led to short term share price increase. Company is proposing to change its name to Cambium Bio, subject to shareholder approval early in 2024. There has been a 133% recovery in 2024 to $2 million with signing of agreement to merge with Cambium Medical Technologies. (15/2/24)RHT - Resonance Health Ltd.
This company has invested so far in Inner Vision Biometrics which is expected to provide only a modest income for some years. However FDA approval for the company's diagnostic provided a short term fillip in early 2005 with a 20% price jump against the downwards sector trend. Introduction of a new strategy to develop business in the US market was not successful and company returned to single revenue income. However, while IVB provides modest revenues, it is now profitable. Company value was $7 million following falls of 30% in 2005 and 78% in 2006 associated with fund raising, market correction and shareholder dissatisfaction. With refocussing of company, prices fell 35% in 2007 and 33% in 2008 with the bright lights being a continuing contract with Novartis and improving financials such that the company became profitable. There have been price oscillations in 2009 (up 180%) with profit and expectations of increasing income as new products and services are introduced. Prices down 25% to $8 million in 2010 apparently associated with GFC and reduced earnings and despite new agreement with Novartis. There was a 57% jump to $12 million in 2011 with signing of product evaluation agreement with Pfizer but there has been some subsequent decline (eventually down 38% in 2011 at $5 million). No great movements in first half of 2012 with submissions to FDA for new tests and annual financials indicating contracting revenues leading to a 31% fall to $3 million. However announcement of FDA interest in FerriScan test and two new clinical trials resulted in doubling of share price in October (eventually up 38% at $6 million). Lack of growth in financials has led to some oscillations in 2013: eventually up 250% at $23 million with new contracts and FDA approval for new test and losses significantly reduced. There was a temporary increase in 2014, eventually down 35% to $16 million with fund raising completed and signs of an expanding market but signature of new agreement to acquire UK company in MRI space dampened the share price and prices recovered once company decided not to proceed with this acquisition. Resignation of Managing Director in early 2015 suggested positive developments for the company with temporary increase in price ( now down 39% at $10 million). The company has returned to profitability for first time in six years and with favourable exchange rate this state should continue and new fibrosis test offers opportunity for more value. Despite this there was a temporary 28% increase in 2016 to $13 million with sales stagnating below projections but company is break even. There has also been a jump associated with increasing involvement in clinical trials and a new test for iron in bone marrow and in sickle cell disease (finally up 4% at $10 million with financials disappointing). There was a 15% decrease in 2017 with company value at $9 million and trials are indicating expanding usefulness of the new tests developed by the company as well as testing of new process accessible through the cloud. Company sales appear to be stagnating and losses, though small, continue. There was an 18% increase in 2018 with company value at $10 million with release of a new screening test for non-alcoholic steatohepatitis (NASH), a new screening test for diabetic retinopathy, a new alliance agreement with a platform company, appointment of new CEO and better promotion to the market. Announcement in December of FDA approval of FerriSmart resulted in 100% jump in prices (eventually up 173% in 2018 at $24 million). There was a further 275% increase in 2019 to $96 million with signing of licensing and distribution agreements, improving financials, new technology patented and company promotion. There was a 31% decrease in 2020 to $69 million with latest financials indicating plateauing revenues and declining profitability, a new agreement opening up US market, new areas of activity and new funds raised This loss was recovered when FDA provided clearance for Hepafat-AI leading to an 80% jump in prices (eventually up 7% at $108 million). There was a further 42% decrease in 2021 to $65 million with a return to profitability and arrival of new MD with some recovery in share price and a move from relying on Channel Partners and a switch to direct sales force in most markets. There appear to be new developments arising from a new antisense oligonucleotide project. FDA approval of LiverSmart at the end of the year resulted in a 45% increase in share price. There was a 57% decrease in 2022 to $28 million with participation in new trials and expansion into the China market as well as better integration into hospital systems through new deal and launch of Resonance Clinical. There was little change in 2023 at $28 million with board more focussed on target market and winning of new substantial health contract. There has been an 18% decrease in 2024 to $22 million with financials improving. (8/2/24)RHY - Rhythm Biosciences Ltd.
Company drawing on CSIRO technology to develop a simple affordable and effective blood test for colorectal cancer. Company listed in early December 2017 and shares rose 40% to company value of $28 million by the end of 2017. There has been a 50% decline in 2018 to $14 million with need to commercialise the technology becoming pressing and change over of CEO. There was a 7% decline in 2019 to $13 million with announcement of three test sites for diagnostic trial and first patients recruited. There was a 68% decrease in 2020 to $4 million but announcement that key biomarker in its test had been validated resulted in a doubling of the share price with new funds raised for expanding clinical trials (eventually up 573% at $176 million with further positive test data). There was a 77% increase in 2021 to $324 million with establishment of US company to speed access to US market and progress in regulation with TGA and EMA of ColoSTAT. There was a 36% decrease in 2022 to $215 million with a 23% increase following announcement of positive clinical trials compared to industry standard and sales starting in New Zealand. There was a 5% decrease in 2023 to $204 million. and a further substantial decrease with withdrawal of application for TGA listing for ColoSTAT in March (eventually down 86% at $30 million) with a change of CEO in process and uncertainty about lead product. Shareholders moved to remove the Executive Chairman which was unsuccessful in an EGM in early 2024. Shares down 11% to $27 million in 2024. (13/2/24)RMD - ResMed Inc.
Shares in the company took a hit in late 2001 with falls from over $10 to under $5. This was followed by patchy but clear improvement to the $6 level (62% increase in 2005 and a 2:1 stock split and even in early 2006). However on release of financials in 2006, there appeared to be a shift in expectations for the company and the share price appeared to have stabilised at a lower level of around $5.40 with subsequen1t growth. The fundamentals of the company are good with substantial turnover and high profitability. The company currently had a market value of around $3.8 billion at the end of 2011 and if continuing positive results are recorded, prices should continue rising (up 21% in 2006 but down 6% in 2007, down 10% in 2008, up 11% in 2009, up 18% in 2010 following stock split but down 29% in 2011 following sudden resignation of CEO, strengthening of A$ and some reorganisation of the company as well as acquisition of an Irish company to extend range as well as declining profitability). There has been a 60% increase to $6.0 billion in 2012 associated with improved financials and recovery in the US market. There was a further 35% increase in 2013 to $7.5 billion with record revenues and profits, a new CEO appointed and patent infringement action successful. There was a drop when first quarter results showed growth levelling off but third quarter financials for FY2014 indicate continuing growth (up 31% in 2014 at $9.7 billion). There was a further 22% increase in 2015 to $11.9 billion but the announcement of a negative clinical trial outcome resulted in a significant fall in the share price (eventually up 7% at $10.4 billion). There was a further 6% increase in 2016 to $11.0 billion with proposal to acquire Brightree for US$800 million to expand connected healthcare solutions followed by a fall and recovery with company having more than 50% of US airflow generator market (eventually up 15% at $12.1 billion). The company is currently involved in cross litigation over patent infringement with Fisher & Paykel Healthcare. There was a 28% increase in 2017 to $15.6 billion with signs that profitability is levelling off despite revenues increasing. There was a further 45% increase in 2018 to $22.7 billion with revenues continuing to increase, profits levelling off and acquisition of MatrixCare for US$750 million. There was a 38% increase in 2019 to $31.4 billion with earnings figures resulting in a share surge. There was a 24% increase in 2020 to $39.3 billion with improving financials. There was a 31% increase in 2021 with company value at $52.113 billion. There was a 13% decrease in 2022 to $45.478 billion with revenues and profit up and announcement of acquisition of German out-of-hospital software solutions company, Medifox Dan for €810 million. There was an 18% decrease in 2023 to $37.418 billion with a fall following announcement of latest results. There has been a 12% recovery in 2024 to $42.053 billion. (8/2/24)RSH - Respiri Ltd.
Previously named Q-Vis then Salus Technologies then Karmelsonix and iSonea in August 2011 before the most recent change in December 2015. Formed from the acquisition of KarmelSonix from Israel and PulmoSonix from Australia to develop respiratory products. Developments were at an early stage and the initial market cap of $8 million following the restructure and fund raising indicated the uncertain status of the company. However, in June/July 2007 prices jumped 502% without explanation but value returned to $4 million (up 243% in 2007 but down 92% in 2008). However, there was a 171% recovery in 2009 which together with fundraising and regulatory approvals raised the market cap to $22 million. Cost cutting was introduced to stop bleed in difficult credit environment. Market cap of the company was not reflected by the fundamentals indicating there were high expectations for this company. Sales of WheezoMeter may provide better fundamentals but sales were still minimal and shares fell 45% in 2010 to market cap of $15 million with a late lift due to yet another reorganisation of the Board and signing of distribution agreements for Europe. Lack of revenue growth relative to projections led to a further 33% fall in 2011 to $12 million. However refinancing of the company and new distribution agreement with Omron initially lifted prices (eventually down 67% at $15 million). A new funding agreement with overseas investor for at least two years offered some future prospects and listing in the US but the market did not respond significantly with little in the way of sales (down 71% to $5 million in mid 2012). There was then a 20:1 consolidation of shares with shares slightly up afterwards and new funds raised (eventually down 50% to $15 million with new key investor). There was an 807% increase to $165 million in 2013 ( eventually up 379% at $89 million in 2013 as speculative push was maintained) with expectations of new smartphone applications providing large returns but possibly caused by entry of new shareholders and it is hard to understand what business model would support this value. A new device associated with smart phone use was launched and company changed name to iSonea and CEO, reorganised the board and engaged new staff to promote marketing and sales. There was a 79% decline in 2014 to $19 million with major changeover of board to promote commercialisation, a new chairman, a new CEO and a new OTC device approved in the US. There was a decrease and recovery to $12 million (down 41%) in 2015 with relaunch of Airsonea product and speculation on the rate of commercialisation. An indication that the company was faltering in its commercialisation was a move to link up with partners for commercialisation. Name changed to Respiri Ltd (ASX:RSH) in December 2015. Shares up 2% in 2016 to $18 million with new funds raised, increasing interest in China, new product development being accelerated and comparisons being made with ResApp Health which is developing a similar product but of higher value. Up 5% to $19 million in 2017 with completion of core software platform and interest from China in manufacturing relationship. There was a further 116% increase in 2018 to $49 million with funds raised for launch of next generation device and significant changeover of board. There was a 26% increase in 2019 to $63 million with Wheezo clinical trial about to start and a new Joint Venture in India but this increase dissipated oncapsede trial started and has recovered with approval for trading in Europe and Australia and reorganisation of the company (eventually up 1% at $54 million). There was a 35% increase in 2020 to $94 million with company planning to transition from a device manufacturer to an eHealth Software as a Service (SaaS) company and has raised funds to this end. The company received a 60% fillip with signing of deals with pharmacy provider, a buy now pay later provider and patient networks as well as positive clinical trial results. There was a 51% decrease in 2021 with company value at $46 million and revenues commencing. The company made a takeover bid for Adherium, another listed company, but this lapsed. There have also been questions about breeches of trading policy by the CEO. There was a 28% decrease in 2022 to $37 million with new funds raised to expand in the US, rollout of wheeze remote patient monitoring systems in US, involvement in new UK asthma trial, speculation on Pfizer acquisition of ResApp Health affecting share prices and trading of shares in the US. There was a 35% decrease in 2023 to $32 million with patient monitoring programs being adopted and reimbursed in North America and move to bolster market support in the US. The company has acquired the US-based remote patient monitoring company Access Managed Services for US$3 million and has expanded its RPM footprint in the US with new clients. There has been a further 30% decrease in 2024 to $22 million. (12/2/24)(SCU - Stemcell United Ltd.)
Singapore-based company using proprietary stem cell technology to culture and grow plant extracts for use in traditional Chinese medicine changed name from On Q Group in September 2015. Since the name change, shares have fallen 87% and in 2016, 83% to a company value of $6 million and were down 7% in 2017 to $5 million. The announcement in March 2017 that company was leveraging its position in complementary medicine to move into medicinal cannabis resulted in shares jumping a highly speculative 1,221% to a company value of $77 million. This speculation persisted with questions being asked about the viability of the company's fundamental business and a further 75% price jump was also unexplained (eventually up 186% at $17 million). There was a decrease and recovery to $12 million in 2018 (down 40%) with an entitlements issue to raise further funds dampening prices (61% shortfall to be underwritten). Speculation over discussions in China on returning to the cannabis story resulted in a short term suspension of share trading and announcement that related Chinese company had gained a hemp licence provided at least a short term recovery. Following this, shares were down 43% at $12 million but there was recently a speculative 50% jump in share prices which remains unexplained (eventually down 53% at $10 million). There was a 26% decrease in 2019 with company value at $9 million following new fund raising and completion of acquisition in China in hemp market. There was a 29% decrease in 2020 to $6 million with a move to increase operations in the cannabis market but following new collaboration in Singapore the price has recovered. There was further stimulation with announcement of new sea farming venture in Singapore and China (eventually up 36% at $15 million). There was a 26% decrease in 2021 to $15 million with funds raised. There was a suspension of share trading in September 2021 re an announcement of joint venture. This has continued to the present although the joint venture has been terminated with revenues up in aquaculture products and losses down and a prospectus is in preparation for return to trading. There has been a change in the board preparatory to an extraordinary meeting with likely changes in shareholdings and shift away from sea-grape production and move to seaweed cultivation. The company is making slow progress to reinstatement and a new funding is in place. Company was reinstated to official quotation on 30 March 2023 and prices fell 71% to company value of $5 million with shareholders voting to change the name of the company to BPH Global (ASX:BP8) which was done in June. (21/6/23)SES - Secos Group Ltd.
Formed from merger of Cardia Bioplastics (ASX:CNN) and Stellar Films Group in April 2015 with merger and associated share consolidation expected to provide impetus for group in Australian and international markets. Market capital of company in 2015 was $14 million (down 45%) after consolidation, new fund raising which was oversubscribed and rationalisation of company with sale of investment holdings. There was a 25% decrease in 2016 to $12 million with more funds raised but there has been a significant recovery in May with annual income now exceeding $20 million (eventually down 27% at $13 million). There has been a decline and recovery in 2017 with Australian and Malaysian operations achieving profitability and new orders coming in (eventually up 25% at $18 million). There was a 35% decrease in 2018 to $18 million with improving sales forecasts, new plant operating in Malaysia and new funds raised to shift manufacturing to Malaysia to reduce costs. There was a further 60% decrease in 2019 to $8 million and a significant recovery with new investment and indications of improving business (eventually up 38% at $36 million). There was a 122% increase in 2020 to $107 million with funds raised despite Coronavirus crisis and a new large contract with US pet food supplier with financial results promising. There was a further 40% increase in 2021 to $150 million with expansion of manufacturing operations in Malaysia and expansion of sales in Australia through Woolworths as well as announcement to invest in establishment of R&D centre. Latest financials indicate company has reached break even. There was a 59% decrease in 2022 to $62 million with financials improving and new contracts in North American market. There was a further 70% decrease in 2023 to $20 million with financials stagnating.There has been a 3% recovery in 2024 to $21 million. (12/2/24)SOM - Somnomed Ltd.
Company listed in August 2004. The company appeared to have a limited range of products and the commercial potential of these did not appear to be great. However, the company has shown steady growth, international coverage and profitability. Share prices were 60% below listing price and had dropped 60% in 2005 until the announcement of FDA approval for sales in the US raised prices temporarily around 50%. They were down 60% overall in 2005 and 88% in 2006 but there was an unexplained temporary jump in early 2007 and then a 40% jump with announcement of improved trading in first half of year (down 5% in 2007). Following substantial fund raising and cost cutting, the company is valued at $40 million and the company will now need to demonstrate significant commercialisation to justify the value. This is beginning to occur (even in 2008 - with improving revenues and positive cash flow and up 115% in 2009 following 20:1 consolidation). There has been a 14% increase in 2010 with reporting of a profitable year and moves to expand the product range. Further increase in early 2011 with improving opportunities for reimbursement in the expanding US market (eventually down 7% to $38 million). There was initially a recovery in early 2012 with the acquisition of a leading Dutch oral appliance distribution company to promote access to the European market and improving financials but despite this, shares down 10% at $35 million). Has also acquired distributors in France and Sweden. There has been a 35% increase to $49 million in 2013 with latest financials indicating marginal profitability and US market developing as well as acquisition of German company in same market. There was a further 145% increase to $137 million in 2014 with indications of significant increases in sales and new markets in Scandinavia and UK. There has been a decrease and recovery in 2015 to $140 million (down 1%) with company maintaining profitability, increasing revenues and gaining new FDA approval for micro recording device as well as acquiring Canadian company with IP in devices for treatment of sleep disordered breathing. Prices up 46% in 2016 with company value at $224 million and sales increasing at 29% with little improvement in profits and planning for roll out of treatment centres to expand sales. There was a 6% decrease in 2017 to $214 million with sales plateauing and profitability falling off. Down 50% to $115 million in 2018 during larger market correction with sales continuing to increase but losses (mainly from direct to consumer business centres which are being closed to reduce costs) increasing. New fund raising was successful and there was a change of management which resulted in a decision to close business centres which led to a 30% increase in share prices. There was a 60% increase in 2019 with company value at $184 million with signs that new management is reducing losses, current users exceed 0.5 million, a new device has gained FDA approval and US market is growing significantly leading to appointment of new staff to service this. There was a 28% decrease to $174 million in 2020 with latest financials indicating company is turning the corner significantly but share price was hit by fund raising during Coronavirus crisis. There has been a major turnover of the board but the outlook remains promising despite a share price decrease during the year. There was a 12% increase in 2021 to $194 million with revenue increases and breakeven and best revenues coming from Europe. There was a 45% decrease in 2022 to $107 million with a new sleep monitoring device, Rest Assure introduced to the market and sales continuing to increase. There was a further 61% decrease in 2023 to $54 million. There has been a 10% decrease in 2024 to $ 49 million. (11/2/24).
SPL - Starpharma Holdings Ltd.
It has been hard to get excited about this company as testified by a downward trend in share price since listing in 2000 until early 2003. Nevertheless, share prices trebled in 2003 and were stable in 2004 but fell 36% in 2005. There was a temporary jump in 2006 associated with fast tracking of VivaGel by the FDA but overall in 2006, there was little change in prices. Potential strength lies in its investment in a US company and the eventual acquisition of this company made sense. We consider that a market cap of $204 million at the end of 2010 was high given annual revenues of $5 million (predominantly government grants and royalties) and annual losses of $7 million. Following speculation, recent awards and recent ADR program, the share price is high (down 16% in 2007 and down 51% in 2008). There was a 256% increase in 2009 which appears to be speculation driven relating to developments with VivaGel and new agreement with Elanco and up 20% in 2010. There was a 37% increase to $320 million in 2011 driven by broker promotion, speculation, signing of condom agreement with Okamoto Industries and potential technology application to a number of sectors, notably the reformulation of anticancer drugs and agrichemicals. The global financial crisis in August reduced prices somewhat but this is recovering now that significant new funds have been raised. There was a 44% increase in 2012 to $465 million associated with speculation over coming clinical trials and clinical and animal trials and when primary endpoint of one clinical trial was not met, this increase was wiped out (eventually up 14% at $369 million). There was a 33% decline in 2013 to $246 million. There was a further 27% decline in 2014 to $181 million with new products incorporating Starpharma technology going on sale in Japan and new agreement with AstraZeneca. This was followed by a recovery in July 2014 with TGA approval for a condom incorporating a Starpharma product (shortly to be launched in Australia) and more funds raised (down 39% at $168 million). There was a 43% increase in 2015 to $273 million with dosage trials providing promising results, AstraZeneca signing a licensing deal and potential treatment for ovarian cancer (questionable). There was a 3% decline in 2016 to $267 million with more funds raised and new licensing deals completed. There was an 88% increase to $504 million in 2017 following FDA approvals for Vivagel BV and successful clinical trials as well as sale of company's agribusiness arm for $35 million and acceptance of the company's technology by AstraZeneca for its next anticancer drug trial. There was a decline and recovery in 2018 to $440 million (even) with signing of licensing agreement with Mundipharma on VivaGel BV and positive indications from anticancer testing. Request by FDA for more data on VivaGel BV in late December resulted in a 30% drop in share price which was soon recovered. There was a 2% increase in 2019 to $451 million with launch of first Vivagel BV products in Australia, Japan and Europe, progress made in the US with approval for Vivagel and a new DEP agreement with AstraZeneca as well as promising results coming from clinical trials underway and research studies. There was a 29% increase in 2020 to $635 million with a new DEP agreement in China. There was a significant share jump with announcement of a repurposed product as an antiviral nasal spray (launched in UK) and an improved remdesivir product for Covid-19 treatment. There was a 14% decrease in 2021 to $544 million with a new agreement with Merck and Genentech and TGA infringement notices associated with advertising of Viraleze. There was a further 59% decrease in 2022 to $225 million with relaunch of Viraleze in UK, new collaborative agreements with large pharma and promising clinical trial results providing a 20% jump. There was a 69% decrease in 2023 to $70 million with AstraZeneca deciding to discontinue development of a drug using SPL technology and positive results from clinical trials. There has been a further 15% decrease in 2024 to $60 million. (5/2/24)SNT - Syntara Ltd.
Company listed as Pharmaxis in November 2003 after which shares dipped but then rose over 700% on the launch price. Prices increased 174% in 2005, 43% in 2006 and 42% in 2007 but fell 71% in 2008 and recovered 125% in 2009. The market cap of the company was $697 million in mid June 2010 ($96 million in cash reserves) which in our view was high for this early stage of the commercialisation cycle. Because of a number of issues including the aggressive push to commercialisation and the global fund raising, speculation has maintained prices. There was a surge in price associated with positive clinical trial results and additional funds were raised in association with this. However the uncertainties on world stock exchanges and delays in critical clinical trials affected prices which fell 34% and recovered but eventually declined 71% in 2008 following publication of improving year end results and broader problems on the stock market. Prices rose 125% in 2009 with promising trial results indicating further price increases are possible. There was an increase of 14% in 2010 with acquisition of Canadian drug developer Topigen Pharmaceuticals in exchange for shares and slow growth in revenues. However announcement of medical intervention on CEO and announcement of Phase III results led to a steep fall in June with a recovery in October with FDA approval for Aridol (shares up 10% with a market cap of $674 million in 2010). There was little movement in 2011 until announcement of delay of European approval for Bronchitol led to a 69% drop to $210 million and this was partly reversed in October when a more positive response was announced (eventually down 65% at $318 million with new funds raised). There was a 20% increase to $400 million in 2012 with indications Bronchitol will be reimbursable in Australia, approvals in Europe and completion of clinical trials but there was a significant decline in May due to general market uncertainty followed by a recovery (eventually up 19% to $383 million). There was a 40% drop to $231 million in January 2013 with a negative recommendation by an advisory committee to the FDA followed up later by confirmation by the FDA (eventually down 91% at $34 million). There was a 51% decline in 2014 to $16 million with Bronchitol shortlisted for a prestigious prize and a legal dispute with key financier. This decline was more than erased at the end of the year when Pharmaxis signed a deal with Chiesi Farma on bronchitol and dispute with financier was settled (eventually up 29% in 2014 at $42 million.) There was a decline and recovery in 2015 with an agreement with Boehringer Ingelheim for a new product, a second agreement with Chiesi and positive clinical trial results of clinical trial of Bronchitol in children (eventually up 167% at $114 million). There was a 22% decline in 2016 to $89 million and a 9% decrease in 2017 to $82 million with improving likelihood of new drug development income and positive clinical trial although results were not as positive as expected. There was a 4% increase in 2018 with company value at $104 million with revenues and profitability up, a new substantial placement and Arix Bioscience taking an 11% holding in the company as well as relaunch of Aridol in the US market. There was a 40% decrease to $63 million in 2019 with positive expectations coming from the US but Boehringer's decision to discontinue work on a NASH product from Pharmaxis resulted in a 45% decrease in late December. There was a further 42% decrease in 2020 to $37 million with clinical trials in process, Bronchitol cleared by the FDA for the US market and orphan drug status for a new product as well as substantial milestone payment. There was a 29% increase to $66 million in 2021 with improving financials, funds raised and new drug indications found. There was a 49% decrease in 2022 to $44 million with tests of potential products promising, fund raising completed and sale of rights to Orbital technology providing short term profitability. There was a 67% decrease in 2023 to $17 million with clinical trial results promising. Company announced a major restructure in which Mannitol business unit would be sold to Arna Pharma, a specialty manufacturing company and the company gained a new business name Syntara following shareholder approval in November. There has been a 5% increase in 2024 to $17 million. (4/2/24)TD1 - TALI Digital Ltd.
Company renamed from Novita Healthcare Ltd (ASX:NHL) in December 2019. Previous company was Avexa, a spinoff from AMRAD. There was a 50% decline of Avexa in 2015 to $7 million with some recovery on announcement of intention to acquire TALI Health and associated 20:1 share consolidation (eventually down 78% at $3 million). There was a further 52% decline in 2016 to $2 million with new funds raised and TALI acquisition completed. Conclusion of this acquisition resulted in some recovery as well as improved publicity and substantial new fund raising (eventually down 61% at $6 million).Name changed to Novita Healthcare Ltd (AX:NHL) in December 2016. There was a 63% increase in 2017 to $16 million with sale or dissolution of legacy businesses, raising of new funds, acquisition of Newly, an online marketplace connecting healthcare professionals with organisations in need and appointment of new CEO. There was a 34% decrease in 2018 to $13 million with launch of first commercial product and changeover of Board with new fund raising and sale of Newly subsidiary. There was a 62% decrease in 2019 to $7 million with implementation of Tali platform in two locations in the US and in Victoria. Prices depressed by entitlement offer which has raised funds. However, announcement in October that use of TALI detect in the US would be reimbursed resulted in a 400% turn around and part maintained with announcement that NDIS would access TALI (eventually up 76% in 2019 at $38 million). Company name changed to TALI Digital (ASX:TD1) occurred on 23/12/2019. There was an 8% decrease in 2020 to $35 million with Google accreditation achieved and funding for rollout in India, but the Coronavirus crisis is depressing prices. There was a 53% decrease in 2021 to $21 million with funds raised for global rollout. There was a further 91% decrease in 2022 to $3 million with change of CEO, Chairman and reorganisation of the company as well as substantial fund raising. There was a 50% decrease in 2023 with company value at $3 million following fund raising, TGA certification of new product and expansion of partnership with Genius Learning and review resulting in phasing out of CEO position. There has been a 100% increase in 2024 to $7 million. (11/2/24)TLX - Telix Pharmaceuticals Ltd.
Company was established in 2017 and listed in November of that year. Innovative company drawing on technology from around the world to develop molecularly targeted radiation (MTR) for diagnosis and cancer therapy with initial focus on prostate, kidney and brain cancer. Premium of 18% on listing ($152 milion) which fell to par by the end of 2017($128 million). There was little change in 20218 with company value at $142 million with a number of international collaborations and clinical trials developing and launch of new imaging product as well as acquisition of Belgian supplier company. There was a 138% increase in 2019 to $393 million with development of a number of programs and preclinical technologies, an NDA submission and new collaborations in the US, Turkey, Japan, Europe and Latin America as well as raising of substantial funds and acquisition of a radiopharmaceutical production facility in Europe. There was an 144% increase in 2020 to $1.06 billion with trials progressing, production facility acquisition completed and new imaging alliances formed although the Coronavirus crisis is depressing prices and delaying trials. There was a 30% share price jump with announcement of a commercial deal for China. Company has acquired Swiss German company in haematology and has announced developments in Korea and the US. There was a 105% increase in 2021 to $2.209 billion with new distribution deals signed, new collaborations and trials progressing well. There was a small fall when FDA indicated it was extending its review of TLX's main product which has now been approved. There was a 6% decrease in 2022 to $2.3 billion with major fundraising completed although share purchase plan was cancelled due to fall in share price and with commencement of expansion of Belgian radiopharmaceutical facility and reorganisation of regional subsidiaries of the company. The unexpected withdrawal of market application for one imaging product resulted in temporary 20% share price fall countered by other international developments including positive trial results. The company is in the process of acquiring Optimal Tracers in California. There was a 39% increase in 2023 to $3.263 billion with revenues up substantially and breakeven achieved in last two quarters as well as proposal to acquire Lightpoint Medical in the UK to expand urological and QSAM Biosciences in the US. There has been a 19% increase in 2024 to $3.894 billion with intention to have an IPO in the US and to list on NASDAQ. (4/2/24)TRI - TrivarX Ltd.
Rebranding of MediBio (AX: MEB) commencing from 16 October 2023. Previously name changed from BioProspect in November 2014 following acquisition of new technology and preparations for new consumer product with substantial reorganisation of company and consolidation in process. Company developed a diagnostic heart rate variability technology for mental health diagnosis and was about to conduct first validation trial. Company value in 2015 was even at $29 million with announcement of agreement with Johns Hopkins for US-based validation trial, 100:1 share consolidation complete, acquisition of diagnostic technology complete with new stress diagnosis technology being patented, positive feedback from recent presentations in North America, early adoption by two companies in Australia and new fund raising completed. There was a 18% decline in 2016 to $26 million but with announcement of results of positive trial, the shares recovered significantly (eventually up 28% at $57 million). There was a 10% decrease in 2017 to $69 million and appointment of new CEO/Managing Director, new agreements with Mayo Clinic, Japan and an Australian provider, appointment of high profile Board members and positive clinical trial results with the aim of gaining FDA clearance in 2018. There was a further 33% decrease in 2018 to $47 million with acquisition of Vital Conversations, a complementary company in the Corporate Wellness market, and signing of corporate contracts for the mental health check. The sudden unexplained departure of the MD/CEO in August resulted in a 31% fall in share price (eventually down 94% at $4 million and aggravated by fund raising). Shareholders representing 6% of the company unsuccessfully tried to replace two directors with three new ones due to dissatisfaction with fall in share price but there were changes at the Board level and reduction of costs in the US. There was a further 57% decrease in 2019 to $2 million with entitlement issue being taken up and a new research agreement in Italy but significant delay in FDA submissions. Announcement in July of a deal with a global company in UK for first of two pilots there resulted in a 190% share price jump to $6 million (even in 2019 at $5 million) but this soon dissipated when company sought funds but jumped again (100%) when a further deal with the same company was announced (down 52% to $10 million with substantial funds raised). Little change in early 2020 with departure of Chairman/MD who has been replaced by key shareholder. There was a 20% decrease in 2020 with company value of $11 million with company programs progressing, a deal signed with Compass, funds raised, outstanding litigation resolved and clinical trail in process. There was a 38% decrease in share price in 2021 with company value of $10 million with CE Mark approval for sleep application, fund raising oversubscribed and launch of new LUCA application. There was a 60% decrease in 2022 to $7 million with new fund raising and arrival of new CEO and Chairman. There was a 50% decrease in 2023 to $5 million but this was reversed with raising of substantial funds to advance clinical trials and roll out of a research tool. Then shares were down 50% at $6 million following raising of funds. AGM in October 2023 agreed to change name of company to TrivarX Ltd (AX:TRI) from mid October 2023 and shares were consolidated 20:1 at the same time (eventually down 25% at $10 million). There has been a further 30% decrease in 2024 to $7 million. (14/2/24)TRP - Tissue Repair Ltd
Clinical stage biopharmaceutical company developing wound healing products for chronic wounds and the aftercare of cosmetic procedures was founded in 2012 with US subsidiary and listed in 2021 at an indicative value of $71 million. There was a 54% decrease in share prices in 2022 to $14 million which is less than current cash holding. There has been a 4% decrease in 2023 to $13 million with peripheral involvement in Silicon Valley Bank problems and FDA approval to proceed to Phase 3 clinical trial of lead product. There has been a further 9% increase in 2024 to $15 million. (8/2/24)TRJ - Trajan Group Holdings Ltd
The company was originally founded in 2021 as Trajan Scientific and Medical and has gradually expanded internationally concentrating on sample collection and testing, pathology, nutrition and laboratory automation and distribution of analytical and pathology products. It listed in mid 2021 at an indicative value of $178 million. The company listed at a premium of 20% and by the end of 2021, share prices had increased a further 100% to over $500 million. There was a 58% decrease in 2022 to $266 million. There was a 29% decrease in 2023 to $188 million. There has been a further 7% decrease in 2024 to $175 million. (14/2/24)TRU - Truscreen Group Holdings Ltd
New Zealand based company founded in 2013 and listed in the ASX at beginning of 2021. The company has developed an accurate and realtime screening diagnosis for cervical cancer which it is distributing into international markets. There was a 50% decrease in share prices in 2022 to $15 million with new CEO appointed and positive promotion and expansion overseas. There was a 48% decrease in 2023 to $9 million with acquisition of associated software company and positive promotion in China and Saudi Arabia was well as improving financials. There has been a 19% increase in 2024 to $10 million with financials improving. (14/2/24)UBI - Universal Biosensors Inc.
Listed in December 2006 with good pedigree and as a result shares jumped 170% on listing and are now up 180% ( up 32% in 2007 review including an unexplained jump in June 2007 and a further jump in October associated with continuing developments with Lifescan) and fund raising. There is significant speculation pushing prices and it remains to be seen how quickly commercialisation can match the current market cap of $245 million (down 60% in 2008, up 214% in 2009 and down 18% in 2010). It would appear that value was affected not only by market downturn but also fact that company was falling behind projections for commercialisation but registration of first product has resulted in substantial price increase and first indications of profitability. The decline in 2010 is probably due to recovery from speculation in 2009 and Global Financial Crisis but positive trials on new product indicates further rises in 2011. However, lack of positive financial results and delays in FDA approval for recent test has dampened prices in 2011 but some recovery provided by new agreements with Siemens Healthcare and Cilag (finally down 51% to $119 million). There was a 19% jump in early 2012 to $141 million with launch of Lifescan product in the US then a decline when end of year financials indicated plateauing revenues. However, half yearly and third quarter financials have indicated significant recovery, reversed by current round of fund raising (up 22% at $159 million). There was an 50% reversal in 2013 to $80 million with half yearly results disappointing investors but a promising outlook with downturn caused by recall of Verio over and new timetable for launch of Siemens product. There was a 57% decrease in 2014 to $34 million when it was revealed that there was a delay in the launch of its new blood coagulation testing device (now launched) and some subsequent recovery when first commercial order from Siemens was received and CE mark gained for new analyser (eventually down 61% at $32 million). There was a 150% increase in 2015 to $79 million with indications of new tests to be incorporated in Siemens test platform and improving income. There was a 31% decline in 2016 to $55 million with financials improving and recent FDA clearance for sale in US of Siemens’s analyser using UBI product as well as new acquisition in Canada. There was a 3% decline in 2017 to $53 million with company maintaining its profitability and income likely to increase substantially. There has been a further 27% decline in 2018 to $39 million with latest financials indicating improved revenues but reduced earnings and resignation of key R&D managers (a recent decision by a client to buy out obligation to pay quarterly licence fees resulted in a short term 45% jump in share prices). There was a 14% decrease in 2019 to company value at $34 million with revenues and profitability up with a transition to a new CEO organised and renegotiations with Siemens completed and share buyback in offing. There was an 129% increase in 2020 to $77 million with appointment of new CEO and announcement of new product for wine industry. There was a 128% increase in 2021 to $176 million with company indicating a change of market strategy, signing of agreements for new cancer detector and new distribution agreements for the wine detector platform which is already being sold and which resulted in a 40% jump in prices. There was a 77% decrease in 2022 to $48 million with launch of new products for the wine industry, raising of substantial new funds and gaining high profile in the academic industry. There was an 11% decrease in 2023 to $42 million with new Chairman, completion of Prothrombin clotting test in the US, launch of Fructose and Acetic Acid Tests, first sales of Xprecia Prime in Europe and India, launch in the US and launch of diabetes test for pet animals was well as improving financials. There has been a 20% decrease in 2024 to $34 million. (13/2/24)UCM - Uscom Ltd.
Listed in 2006 but as sales were slower than projected, prices declined initially, but there was a late jump in prices possibly associated with speculation on future sales (up 25% in 2006). In 2007, there was a 73% fall in prices followed by a partial recovery and then a further fall with an unexplained recovery (up 67% in 2008) and a further 61% recovery in 2009. The company had a market cap of $3 million at the end of 2011, eight years after listing with revenues still limited. Company strengthened by distributor taking major position on share register. There was a 58% decline in 2010 due to declining sales and increasing losses. Changeover of chairman and refocussing of the company in late December 2010 with further capital injections and board changes offers hope for the new year. There have been price oscillations in 2011 (down 77%) with further fund raising but annual sales have dropped below $1 million. This has not been helped by disagreements at Board level over company management and direction with the major shareholder prevailing and the new guard departing with major changes to the Board and management and further depression of the share price. There was a 199% rise in 2012 (to $13 million) with improving sales but continuing losses and new funds raised. The company has acquired NZ company Pulsecor for $2.4 million in shares (down 30% in 2013 at $11 million with new funds raised.) Shares up 43% in 2014 to market cap of $16 million with new markets opening in China, Canada, the Netherlands, Germany and Scandinavia and a new report rating Uscom products highly as well as measurement of central blood pressure for hypertension. Shares down 13% in 2015 at $17 million with new applications for USCOM products being found, new distribution agreements signed, new sales executives signed and acquisition of Thor Laboratories, a respiratory function device company in Hungary. There was a 40% increase in 2016 to $27 million with sale of product into UK NHS system and positive results from Thailand as well as new funds raised and new deals in Vietnam and China leading to manufacturing uptick. There was a 14% decrease to $29 million in 2017 with revenues increasing slowly, new partnerships formed in Europe and significant new key investor and placement adding substantial funds. There was a 31% decrease in 2018 with company value at $20 million with release of new hypertension assessment product and there was a 14% decrease in 2019 to $18 million. There was a 238% increase in 2020 to $61 million due to speculation that the use of Uscom devices to monitor coronavirus patients in China is leading to an increase in demand and indications that Uscom technology is promoted for monitoring of sepsis in children. However this speculation has faded (eventually up 33% at $25 million) with financials improving slowly and new products released. There was a 28% decrease in 2021 to $23 million and a further 61% decrease in 2022 to $9 million with agreement for future manufacture in Beijing and opportunities expanding for products in the US and South East Asia. There was a 9% decrease in 2023 to $8 million. There has been a further 20% decrease in 2024 to $6 million. (14/2/24)